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SCI-E Article

Single-cell analysis of gastric pre-슬롯사이트 지니ous and 슬롯사이트 지니 lesions reveals cell lineage diversity and intratumoral heterogeneity

	성명	조수영 ()
	소속	과학기술융합슬롯사이트 지니 분자생명과학과
	캠퍼스
	우수선정주	2022년 02월 3째주

슬롯사이트 지니

조수영 (Dept Mol & Life Sci) corresponding 슬롯사이트 지니;

Corresponding 슬롯사이트 지니 Info

Cho, SY (corresponding 슬롯사이트 지니), Natl Canc Ctr, 323 Ilsan Ro, Goyang Si 10408, Gyeonggi Do, South Korea.; Nam, KT (corresponding 슬롯사이트 지니), Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Brain Korea 21 PLUS Project Med Sci, Seoul 03722, South Korea.; Lee,

E-mail

sooycho@hanyang.ac.kr

Document Type

Article

Source

NPJ PRECISION ONCOLOGYVolume:6 Issue:1 Pages:- Published:2022

Times Cited

External Information

Abstract

Single-cell transcriptomic profiles analysis has proposed new insights for understanding the behavior of human gastric 슬롯사이트 지니 (GC). GC offers a unique model of intratumoral heterogeneity. However, the specific classes of cells involved in carcinogenetic passage, and the tumor microenvironment of stromal cells was poorly understood. We characterized the heterogeneous cell population of pre슬롯사이트 지니ous lesions and gastric 슬롯사이트 지니 at the single-cell resolution by RNA sequencing. We identified 10 gastric cell subtypes and showed the intestinal and diffuse-type 슬롯사이트 지니 were characterized by different cell population. We found that the intestinal and diffuse-type 슬롯사이트 지니 cells have the differential metaplastic cell lineages: intestinal-type 슬롯사이트 지니 cells differentiated along the intestinal metaplasia lineage while diffuse-type 슬롯사이트 지니 cells resemble de novo pathway. We observed an enriched CCND1 mutation in premalignant disease state and discovered 슬롯사이트 지니-associated fibroblast cells harboring pro-stemness properties. In particular, tumor cells could be categorized into previously proposed molecular subtypes and harbored specific subtype of malignant cell with high expression level of epithelial-myofibroblast transition which was correlated with poor clinical prognosis. In addition to intratumoral heterogeneity, the analysis revealed different cellular lineages were responsible for potential carcinogenetic pathways. Single-cell transcriptomes analysis of gastric pre-슬롯사이트 지니ous lesions and 슬롯사이트 지니 may provide insights for understanding GC cell behavior, suggesting potential targets for the diagnosis and treatment of GC.

Web of Science Categories

Oncology

Funding

National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2018R1C1B6001475, NRF-2019R1A2C1003401, NRF-2021R1A2C1009415]; National 슬롯사이트 지니 Center Grant [1711290, 2110050]

Language

English

attached file